Now the traditional antagonists in the region can get back to fighting each other.
The success of the Syrian government forces inevitably raises the potential for clashes between them and US-backed, predominantly Kurdish units who hold a significant swathe of northern Syria.
It is a powerful reminder that while the war against the IS “caliphate” is well on the way to being won, the situation on the ground in Syria is becoming ever more complex.
With Iran eager to consolidate its influence, questions remain as to the Trump administration’s future policy direction now IS is collapsing. Syrian President Bashar al-Assad has consolidated his position and looks to squeeze opposition forces in the months ahead.